ENThe paper investigates the challenges and opportunities that entrepreneurial university faced in the present context, focusing on some characteristics of Romania and Lithuania. Emerged as a concept that is designated to enhance the university’s competitiveness, by integrated more efficient the business environment requirements, with the particularities of the higher education process, entrepreneurial university concept still raise a lot of comments. A large literature has developed around the concept. However, countries from Eastern and Central Europe constitute a particular example, as long as their experience in a market economy is limited. It is in the intention of this paper to explain some of these characteristics and why this hybrid concept is fragile in demonstrating the efficiency of higher education.