ENRussia is the largest foreign trade partner of Lithuania. The aim of the article is to analyze the changes in the foreign trade of Lithuania that occurred as a result of economic sanctions directed against Russia. The object of the research was the structure of export and import of Lithuania according to the SITC classification and the countries of destination. The article uses comparative research method to investigate the changes in the foreign trade of Lithuania in the period before the sanctions and after the introduction of sanctions – thus the investigation covered the period between 2012 and 2015. In the analyzed period foreign trade of Lithuania underwent significant changes both in the structure of trade and the countries of destination.