ENThe article “Trade in alcohol in the Grand Duchy of Lithuania and participation Jews in it (in the end of XIV – 1572)” the author used numerous published sources. He explores: the emergence of alcoholic beverages, legal conditions for such trade, taxation and its and profitability, activity alcohol trade institutions, competition between traders of alcohol, the composition of the merchants alcohol, extension of drunkenness. The author found that the number of Jewish institutions alcohol trade increased, but most of them were in the hands of Christians. Nonetheless, manifestations of economic antisemitism took place. Keywords: Grand Duchy of Lithuania, Belarus, trade, alcohol, karchma (tavern), Jews, the economic antisemitism.