ENThe article is an attempt at presenting the history of the publishing houses in the Grand Duchy of Lithuania in the 17th century. Printing houses - and Cyrillic printing houses in general - in the Grand Duchy of Lithuania were founded in places where people of the Orthodox Church or Union religions were the predominating group. Many details depended also on wealthy patrons, and that is why the publishing houses were founded in places where the support of the powerful and wealthy could be found, i.e. in Vilnius, Jev, Mogilev, Kutein, and Zabudova. The Union of Lublin and the Union of Brzesko contributed to an increase of pressures on the Orthodox Church and its believers causing various kinds of obstacles in the activity of the printing houses on one hand, and released great energy lurking in the society on the other. This fact explains the foundation of many Orthodox monasteries with printing houses. The monasteries became important spiritual and intellectual centers of the Orthodox Church They played a major part in the endurance of this particular religion in the Ruthenian lands of the Crown and Grand Duchy of Lithuania.