ENEconomic and technological internationalization and development of new forms of economic, social and technological headway designed to create and further improve economies based on knowledge and high technologies sector in the European Union are analyzed here. The main emphasis is put on strategic decisions in the area of economic and technological internationalization, knowledge economy and high technologies sectors creation and further modernization as well as creation of scientific and technological progress oriented networks of clusters. High technology sectors development and clusterization oriented towards an increase of efficiency of various national and regional economies is a critical precondition for successful creation of the modern economy based on knowledge, both in the whole space of the European Union and particular countries. A concept of creation of regional and cross-regional clusters and their networks also known as „economic oazes“ is suggested here. It is explained that in the economies based on knowledge development of clusters and their networks will soon become one of the core forms of economic and technological advancement.The idea of international clusterization generally oriented towards creation and promotion of high technologies is given. Some typical factors of the economic, technological and social development of the European Union are being described here, and it is subsequently proved that these factors reflect on the common context of creation of the knowledge based economies. Understanding these factors allows us to consequently implement strategies of two types that could create the economies based on knowledge: these are the strategies oriented towards integration of the processes of economic, technological and social development along with the strategies oriented towards the syntesis of the results of the economic endeavours and technology advancement of different origins. The promotion of the patterns based on the ideas of integration and synthesis is a core prerequisite for encouragement of innovations and improvement of technology transmition systems. Further research dedicated to the patterns mentioned above, is a promising trend of the science of economics as well as the science of management and administration directly connected to the needs for creation of knowledge based economies and internationalization processes in the European Union.