ENDespite advantages, Information and Communication technologies (ICT) development causes certain challenges for business entities, public organizations, and society. E-supply chain, as a phenomenon is not an exception. The needs and requirements of e-commerce logistics become one of most important drivers for logistics and physical distribution networks change. Over last decades this area changed dramatically. At the moment, with the growth of e-commerce, most of the shippers, especially multi-channel shippers, are just starting to develop their own distribution network infrastructure. Since year 2000 e-commerce started to expand rapidly with the „pure-play“ (online only) retailers, which enabled establishing of e-fulfillment distribution networks, the medical products e-commerce lack behind in terms of traditional e-commerce. Reason for this – specifics of product itself. First – huge part of medical products need recipes, and health care system (e-health) in country should be ready (like e-recipe). Such decisions in EU countries are quite new. For example, creation of e-health system for citizens in Lithuania started in 2005 [p. 29].